Desmond A Schatz, M.D.
Professor Of Pediatrics, Medical Director, Diabetes Institute
About Desmond A Schatz
I am a Professor and Medical Director of the Diabetes Institute and Director of the Clinical Research Center within the CTSI at the University of Florida, Gainesville. I served as President of Science and Medicine of the American Diabetes Association in 2016. I have been involved in Type 1 diabetes research since the mid 1980’s and have published over 400 manuscripts, the majority related to the prediction, natural history, genetics, immunopathogenesis and prevention of the disease, as well as the management of children and adolescents with Type 1 diabetes. I am the Principal Investigator (PI) on several NIH awards, and I am the PI of the University of Florida Clinical Center participating in the NIH-funded TrialNet (a founding member of the DPT-1 in 1994). I am co-PI on a Program Project Grant seeking to understand the immunopathogenesis of Type 1 diabetes, and also serve as PI for the NIH-funded international newborn genetic screening (TEDDY) program in North Central Florida. I am the PI on the NIH-funded Human Islet Research Network (HIRN) Grant evaluating novel markers and mechanisms of beta cell destruction, as well as, the PI of the University of Florida site participating in the Type 1 Diabetes Exchange. I have served in numerous capacities (Committees, Study Sections) for the American Diabetes Association, JDRF and NIH. I am the recipient of multiple awards including the Mary Tyler Moore and S Robert Levine JDRF Excellence in Clinical Research Award, the 2009 Cure Award from the American Diabetes Association, the 2010 Public Policy Leadership Award, the prestigious Banting Medal for service from the American Diabetes Association, the ISPAD Prize for achievement (the highest honor of the International Society for Pediatric and Adolescent Diabetes) both in 2016 and, more recently in 2021, the distinguished George Eisenbarth Award from the JDRF for outstanding research advances toward the prevention of Type 1 diabetes. In 2022 I was elected into the prestigious Academy of Science, Engineering and Medicine of Florida (ASEMFL).
Accomplishments
Member, Academy of Science, Engineering and Medicine of Florida (ASEMFL).
2022
·
Academy of Science, Engineering and Medicine of Florida (ASEMFL)
George Eisenbarth Award
2021
·
Juvenile Diabetes Research Foundation (JDRF)
ISPAD Prize for highest achievement
2016
·
International Society for Pediatric and Adolescent Diabetes)
Banting Medal for service
2016
·
American Diabetes Association
Faculty
2013
·
Alpha Omega Alpha (AOA) National Medical Society
Public Policy Leadership Award
2010
·
American Diabetes Association
Cure Award
2009
·
American Diabetes Association
Clinical Research
2008
·
Juvenile Diabetes Foundation
Teaching Profile
Courses Taught
2018
MDT7400 Elect Top/Pediatrics
2018
MDC7400 Pediatric Clerkship
Board Certifications
-
Pediatric EndocrinologyAmerican Board of Pediatrics
-
PediatricsAmerican Board of Pediatrics
Clinical Profile
Specialties
- Pediatrics
Subspecialties
- Pediatric Endocrinology
Areas of Interest
- Diabetes
- Endocrine glands
- Type 1 diabetes
Research Profile
Areas of Interest
- Pediatric Endocrinology
- Type 1 Diabetes
Open Researcher and Contributor ID (ORCID)
0000-0002-1044-5762
Publications
2024
5-Year simulation of diabetes-related complications in people treated with tirzepatide or semaglutide versus insulin glargine.
Diabetes, obesity & metabolism.
26(2):463-472
[DOI] 10.1111/dom.15332.
[PMID] 37867175.
2024
DNA Methylation-Based Assessment of Cell Composition in Human Pancreas and Islets.
Diabetes.
73(4):554-564
[DOI] 10.2337/db23-0704.
[PMID] 38266068.
2024
Immune Intervention and Replacement Therapies in Type 1 Diabetes.
Diabetes technology & therapeutics.
26(S1):S212-S218
[DOI] 10.1089/dia.2024.2514.
[PMID] 38441454.
2024
Low-Dose Antithymocyte Globulin: A Pragmatic Approach to Treating Stage 2 Type 1 Diabetes.
Diabetes care.
47(2):285-289
[DOI] 10.2337/dc23-1750.
[PMID] 38117469.
2023
A genomic data archive from the Network for Pancreatic Organ donors with Diabetes.
Scientific data.
10(1)
[DOI] 10.1038/s41597-023-02244-6.
[PMID] 37237059.
2023
Barriers to Screening: An Analysis of Factors Impacting Screening for Type 1 Diabetes Prevention Trials.
Journal of the Endocrine Society.
7(3)
[DOI] 10.1210/jendso/bvad003.
[PMID] 36741943.
2023
CGM Metrics Identify Dysglycemic States in Participants From the TrialNet Pathway to Prevention Study
Diabetes Care.
46(3):526-534
[DOI] 10.2337/dc22-1297.
[PMID] 36730530.
2023
Consensus Recommendations for the Use of Automated Insulin Delivery Technologies in Clinical Practice
Endocrine Reviews.
44(2):254-280
[DOI] 10.1210/endrev/bnac022.
[PMID] 36066457.
2023
Ethnic Variations in Cardiovascular and Renal Outcomes From Newer Glucose-Lowering Drugs: A Meta-Analysis of Randomized Outcome Trials.
Journal of the American Heart Association.
12(10)
[DOI] 10.1161/JAHA.122.026791.
[PMID] 37158069.
2023
Human immune phenotyping reveals accelerated aging in type 1 diabetes.
JCI insight.
8(17)
[DOI] 10.1172/jci.insight.170767.
[PMID] 37498686.
2023
Immune Intervention and Replacement Therapies in Type 1 Diabetes.
Diabetes technology & therapeutics.
25(S1):S201-S206
[DOI] 10.1089/dia.2023.2513.
[PMID] 36802187.
2023
Modeling the progression of Type 2 diabetes with underlying obesity.
PLoS computational biology.
19(2)
[DOI] 10.1371/journal.pcbi.1010914.
[PMID] 36848379.
2023
Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes.
JCI insight.
8(16)
[DOI] 10.1172/jci.insight.161812.
[PMID] 37432736.
2023
The ISPAD Clinical Practice Consensus Guidelines 2022: how far we have come and the distance still to go.
The lancet. Diabetes & endocrinology.
11(5):304-307
[DOI] 10.1016/S2213-8587(23)00083-9.
[PMID] 36972713.
2023
The role of health system penetration rate in estimating the prevalence of type 1 diabetes in children and adolescents using electronic health records.
Journal of the American Medical Informatics Association : JAMIA.
31(1):165-173
[DOI] 10.1093/jamia/ocad194.
[PMID] 37812771.
2023
Time for changes in type 1 diabetes intervention trial designs.
The lancet. Diabetes & endocrinology.
11(11):789-791
[DOI] 10.1016/S2213-8587(23)00262-0.
[PMID] 37802093.
2023
Type 1 Diabetes: A Disorder of the Exocrine and Endocrine Pancreas.
Journal of cellular immunology.
5(4):120-126
[DOI] 10.33696/immunology.5.177.
[PMID] 38390030.
2022
A Comparison of Postprandial Glucose Control in the Medtronic Advanced Hybrid Closed-Loop System Versus 670G.
Diabetes technology & therapeutics.
24(8):573-582
[DOI] 10.1089/dia.2021.0568.
[PMID] 35363054.
2022
Cost-Effectiveness of Low-Dose Antithymocyte Globulin Versus Other Immunotherapies for Treatment of New-Onset Type 1 Diabetes.
Diabetes technology & therapeutics.
24(4):258-267
[DOI] 10.1089/dia.2021.0329.
[PMID] 34704801.
2022
Improving the Prediction of Type 1 Diabetes Across Ancestries.
Diabetes care.
45(3):e48-e50
[DOI] 10.2337/dc21-1254.
[PMID] 35043156.
2022
Incidence Trends of New-Onset Diabetes in Children and Adolescents Before and During the COVID-19 Pandemic: Findings From Florida.
Diabetes.
71(12):2702-2706
[DOI] 10.2337/db22-0549.
[PMID] 36094294.
2022
Index60 Is Superior to HbA1c for Identifying Individuals at High Risk for Type 1 Diabetes.
The Journal of clinical endocrinology and metabolism.
107(10):2784-2792
[DOI] 10.1210/clinem/dgac440.
[PMID] 35880956.
2022
Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests.
Diabetes care.
45(10):2342-2349
[DOI] 10.2337/dc22-0828.
[PMID] 36150054.
2022
Small steps forward: Adjunctive therapy for T1D.
Journal of diabetes.
14(10):642-645
[DOI] 10.1111/1753-0407.13326.
[PMID] 36205524.
2022
The progression of secondary diabetes: A review of modeling studies.
Frontiers in endocrinology.
13
[DOI] 10.3389/fendo.2022.1070979.
[PMID] 36619543.
2021
A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial.
Lancet (London, England).
397(10270):208-219
[DOI] 10.1016/S0140-6736(20)32514-9.
[PMID] 33453783.
2021
A unified mathematical model of thyroid hormone regulation and implication for personalized treatment of thyroid disorders.
Journal of theoretical biology.
528
[DOI] 10.1016/j.jtbi.2021.110853.
[PMID] 34358537.
2021
Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrPC, in type 1 diabetes
Diabetologia.
64(10):2279-2291
[DOI] 10.1007/s00125-021-05501-8.
[PMID] 34274990.
2021
An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood.
Diabetes care.
44(10):2260-8
[DOI] 10.2337/dc20-2122.
[PMID] 33627366.
2021
Defining a cure for type 1 diabetes: a call to action.
The lancet. Diabetes & endocrinology.
9(9):553-555
[DOI] 10.1016/S2213-8587(21)00181-9.
[PMID] 34339632.
2021
Delayed diagnosis of diabetic ketoacidosis and associated mortality during the COVID-19 pandemic.
Journal of diabetes.
13(10):837-839
[DOI] 10.1111/1753-0407.13208.
[PMID] 34196115.
2021
Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.
Diabetes.
70(4):944-954
[DOI] 10.2337/db20-0995.
[PMID] 33441381.
2021
Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.
Diabetes.
70(4):932-943
[DOI] 10.2337/db20-0937.
[PMID] 33419759.
2021
How Do We Move Type 1 Diabetes Immunotherapies Forward During the Current COVID-19 Pandemic?
Diabetes.
70(5):1021-1028
[DOI] 10.2337/dbi20-0045.
[PMID] 33632743.
2021
IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes.
JCI insight.
6(21)
[DOI] 10.1172/jci.insight.150074.
[PMID] 34747368.
2021
Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas.
The American journal of pathology.
191(3):454-462
[DOI] 10.1016/j.ajpath.2020.11.010.
[PMID] 33307036.
2021
Immune Intervention in Type 1 Diabetes.
Diabetes technology & therapeutics.
23(S2):S179-S184
[DOI] 10.1089/dia.2021.2513.
[PMID] 34061634.
2021
Index60 as an additional diagnostic criterion for type 1 diabetes.
Diabetologia.
64(4):836-844
[DOI] 10.1007/s00125-020-05365-4.
[PMID] 33496819.
2021
Insulin immunotherapy for pretype 1 diabetes.
Current opinion in endocrinology, diabetes, and obesity.
28(4):390-396
[DOI] 10.1097/MED.0000000000000648.
[PMID] 34091488.
2021
Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes.
Genome biology.
22(1)
[DOI] 10.1186/s13059-021-02262-w.
[PMID] 33478573.
2021
Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes.
Scientific reports.
11(1)
[DOI] 10.1038/s41598-021-85659-8.
[PMID] 33753784.
2021
Lived Experience of Advanced Hybrid Closed-Loop Versus Hybrid Closed-Loop: Patient-Reported Outcomes and Perspectives.
Diabetes technology & therapeutics.
23(12):857-861
[DOI] 10.1089/dia.2021.0153.
[PMID] 34270328.
2021
Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report
Diabetes.
70(5):1123-1129
[DOI] 10.2337/db20-1103.
[PMID] 33632742.
2021
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes.
Diabetes.
70(8):1885-1897
[DOI] 10.2337/db21-0070.
[PMID] 34035041.
2021
Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies.
Frontiers in endocrinology.
12
[DOI] 10.3389/fendo.2021.778912.
[PMID] 34912300.
2021
The influence of selection bias on identifying an association between allergy medication use and SARS-CoV-2 infection.
EClinicalMedicine.
37
[DOI] 10.1016/j.eclinm.2021.100936.
[PMID] 34104879.
2020
Addressing health disparities in type 1 diabetes through peer mentorship.
Pediatric diabetes.
21(1):120-127
[DOI] 10.1111/pedi.12935.
[PMID] 31617648.
2020
An Iterative Process for Identifying Pediatric Patients With Type 1 Diabetes: Retrospective Observational Study
JMIR Medical Informatics.
8(9)
[DOI] 10.2196/18874.
[PMID] 32886067.
2020
Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.
Diabetes technology & therapeutics.
22(12):948-953
[DOI] 10.1089/dia.2020.0305.
[PMID] 32833543.
2020
Exocrine Pancreas Dysfunction in Type 1 Diabetes.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
26(12):1505-1513
[DOI] 10.4158/EP-2020-0295.
[PMID] 33471743.
2020
Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study
Diabetes Care.
43(9):2066-2073
[DOI] 10.2337/dc19-2547.
[PMID] 32641373.
2020
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.
Diabetic medicine : a journal of the British Diabetic Association.
37(12):2160-2168
[DOI] 10.1111/dme.14361.
[PMID] 32634859.
2020
Immune Intervention in Type 1 Diabetes.
Diabetes technology & therapeutics.
22(S1):S141-S148
[DOI] 10.1089/dia.2020.2511.
[PMID] 32069151.
2020
Insulin dose optimization using an automated artificial intelligence-based decision support system in youths with type 1 diabetes.
Nature medicine.
26(9):1380-1384
[DOI] 10.1038/s41591-020-1045-7.
[PMID] 32908282.
2020
Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis
Diabetes.
69(3):413-423
[DOI] 10.2337/db19-0942.
[PMID] 31826866.
2020
Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.
Diabetes care.
43(1):5-12
[DOI] 10.2337/dc19-0880.
[PMID] 31753960.
2020
Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells.
JCI insight.
5(14)
[DOI] 10.1172/jci.insight.136579.
[PMID] 32573495.
2020
Slowed Metabolic Decline After 1 Year of Oral Insulin Treatment Among Individuals at High Risk for Type 1 Diabetes in the Diabetes Prevention Trial-Type 1 (DPT-1) and TrialNet Oral Insulin Prevention Trials.
Diabetes.
69(8):1827-1832
[DOI] 10.2337/db20-0166.
[PMID] 32439823.
2020
Teaching Type 1 Diabetes: Creating Stakeholder Engagement in Biomedical Careers Through Undergraduate Research Curriculum
Medical Science Educator.
30(1):69-73
[DOI] 10.1007/s40670-019-00877-0.
[PMID] 34457640.
2020
Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues
Diabetes.
69(1):60-66
[DOI] 10.2337/db19-0554.
[PMID] 31597639.
2020
The Discovery and Structure of Human Insulin.
Pediatric endocrinology reviews : PER.
17(Suppl 1):131-137
[DOI] 10.17458/per.vol17.2020.zfs.discoverystructureinsulin.
[PMID] 32208558.
2020
Use of Ecological Momentary Assessment to Measure Self-Monitoring of Blood Glucose Adherence in Youth With Type 1 Diabetes.
Diabetes spectrum : a publication of the American Diabetes Association.
33(3):280-289
[DOI] 10.2337/ds19-0041.
[PMID] 32848350.
2019
An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.
The New England journal of medicine.
381(7):603-613
[DOI] 10.1056/NEJMoa1902226.
[PMID] 31180194.
2019
Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk
Jama-Journal of the American Medical Association.
322(6):514-523
[DOI] 10.1001/jama.2019.10329.
[PMID] 31408136.
2019
Bringing closure: towards achieving a better understanding of Israel.
Lancet (London, England).
394(10198)
[DOI] 10.1016/S0140-6736(19)31760-X.
[PMID] 31376991.
2019
Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range
Diabetes Care.
42(8):1593-1603
[DOI] 10.2337/dci19-0028.
[PMID] 31177185.
2019
Designing Online and Mobile Diabetes Education for Fathers of Children With Type 1 Diabetes: Mixed Methods Study
JMIR Diabetes.
4(3)
[DOI] 10.2196/13724.
[PMID] 31389338.
2019
Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk
Nutrients.
11(8)
[DOI] 10.3390/nu11081790.
[PMID] 31382440.
2019
Enhanced Understanding of the Natural History of Pre-Type 1 Diabetes: Fundamental to Prevention.
Pediatric endocrinology reviews : PER.
16(3):359-368
[DOI] 10.17458/per.vol16.2019.bs.pretype1diabetes.
[PMID] 30888126.
2019
Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome.
Nature communications.
10(1)
[DOI] 10.1038/s41467-019-11460-x.
[PMID] 31399563.
2019
Immune Intervention in Type 1 Diabetes.
Diabetes technology & therapeutics.
21(S1):S95-S100
[DOI] 10.1089/dia.2019.2507.
[PMID] 30785317.
2019
Immunomodulatory activity of humanized anti-IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes.
JCI insight.
4(24)
[DOI] 10.1172/jci.insight.126054.
[PMID] 31852846.
2019
International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium-Glucose Cotransporter (SGLT) Inhibitors.
Diabetes care.
42(6):1147-1154
[DOI] 10.2337/dc18-2316.
[PMID] 30728224.
2019
Is It Time to Prioritize Diabetes Prevention in Practice?
Journal of the American Board of Family Medicine : JABFM.
32(4):457-459
[DOI] 10.3122/jabfm.2019.04.190114.
[PMID] 31343975.
2019
Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data
Diabetes.
68(6):1267-1276
[DOI] 10.2337/db19-0057.
[PMID] 30967424.
2019
Metabolite-related dietary patterns and the development of islet autoimmunity
Scientific Reports.
9(1)
[DOI] 10.1038/s41598-019-51251-4.
[PMID] 31616039.
2019
Objectively Measured Adherence in Adolescents With Type 1 Diabetes on Multiple Daily Injections and Insulin Pump Therapy.
Journal of pediatric psychology.
44(1):21-31
[DOI] 10.1093/jpepsy/jsy064.
[PMID] 30184209.
2019
Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children
Pediatric Diabetes.
20(3):263-270
[DOI] 10.1111/pedi.12812.
[PMID] 30628751.
2019
Prospective virome analyses in young children at increased genetic risk for type 1 diabetes.
Nature medicine.
25(12):1865-1872
[DOI] 10.1038/s41591-019-0667-0.
[PMID] 31792456.
2019
Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.
Diabetes care.
42(2):281-287
[DOI] 10.2337/dc18-1512.
[PMID] 30552130.
2019
Teaching type 1 diabetes: creating stakeholder engagement in biomedical careers through undergraduate research curriculum
.
2019
The association between stressful life events and respiratory infections during the first 4 years of life: The Environmental Determinants of Diabetes in the Young study
Stress and Health.
35(3):289-303
[DOI] 10.1002/smi.2861.
[PMID] 30768831.
2019
The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening
Diabetologia.
63(3):588-596
[DOI] 10.1007/s00125-019-05047-w.
[PMID] 31768570.
2018
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Scientific reports.
8(1)
[DOI] 10.1038/s41598-018-22574-5.
[PMID] 29540798.
2018
Geographic Access to Endocrinologists for Florida’s Publicly Insured Children with Diabetes
The American Journal Of Managed Care.
24(4):104-107
2018
Growth hormone and insulin-like growth factor-I axis in type 1 diabetes
Growth Hormone & IGF Research.
38:49-52
[DOI] 10.1016/j.ghir.2017.12.005.
2018
Hospital time prior to death and pancreas histopathology: implications for future studies.
Diabetologia.
61(4):954-958
[DOI] 10.1007/s00125-017-4494-x.
[PMID] 29128936.
2018
Immune Intervention for Type 1 Diabetes.
Diabetes technology & therapeutics.
20(S1):S86-S93
[DOI] 10.1089/dia.2018.2507.
[PMID] 29437480.
2018
Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes
Diabetes Care.
41(9):1917-1925
[DOI] 10.2337/dc18-0494.
[PMID] 30012675.
2018
Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.
The Journal of clinical endocrinology and metabolism.
103(1):35-45
[DOI] 10.1210/jc.2017-01159.
[PMID] 28938416.
2018
Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes—The TrialNet Experience
Diabetes.
67(7):1216-1225
[DOI] 10.2337/db18-0065.
[PMID] 29769238.
2018
The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.
Current diabetes reports.
18(12)
[DOI] 10.1007/s11892-018-1113-2.
[PMID] 30353256.
2018
Transition Education for Young Adults With Type 1 Diabetes: Pilot Feasibility Study for a Group Telehealth Intervention
JMIR Diabetes.
3(4)
[DOI] 10.2196/10909.
[PMID] 30401674.
2018
Type 1 Diabetes in Children and Adolescents: A Position Statement by the American Diabetes Association
Diabetes Care.
41(9):2026-2044
[DOI] 10.2337/dci18-0023.
[PMID] 30093549.
2018
Type 1 Diabetes TrialNet Study Group: A Type 1 Diabetes genetic risk score predicts progression of islet autoimmunity and development of type 1 diabetes in individuals at risk
Diabetes Care.
41(9):1887-1894
2018
Understanding Pre-Type 1 Diabetes: The Key to Prevention.
Frontiers in endocrinology.
9
[DOI] 10.3389/fendo.2018.00070.
[PMID] 29559955.
2017
Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity.
JAMA pediatrics.
171(12):1217-1225
[DOI] 10.1001/jamapediatrics.2017.2905.
[PMID] 29052687.
2017
Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis
Diabetes.
66(2):241-255
[DOI] 10.2337/db16-0806.
[PMID] 27980006.
2017
Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes: A Randomized Clinical Trial.
JAMA.
318(19):1891-1902
[DOI] 10.1001/jama.2017.17070.
[PMID] 29164254.
2017
Erratum. 2016 Presidential Address: Diabetes at 212°-Confronting the Invisible Disease. Diabetes Care 2016;39:1657-1663.
Diabetes care.
40(5)
[DOI] 10.2337/dc17-er05a.
[PMID] 28302650.
2017
Factors That Influence the Quality of RNA From the Pancreas of Organ Donors.
Pancreas.
46(2):252-259
[DOI] 10.1097/MPA.0000000000000717.
[PMID] 27984510.
2017
High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes
Diabetes Care.
40(9):e122-e123
[DOI] 10.2337/dc17-0996.
2017
Immune Interventions for Type 1 Diabetes Mellitus.
Diabetes technology & therapeutics.
19(S1):S74-S81
[DOI] 10.1089/dia.2017.2507.
[PMID] 28192018.
2017
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The Journal of clinical endocrinology and metabolism.
95(7):3360-7
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2010
Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease.
Diabetologia.
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2010
Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.
PloS one.
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2010
The Pediatric Diabetes Consortium: Improving Care of Children With Type 1 Diabetes Through Collaborative Research
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2010
Type I diabetes. Preface.
Endocrinology and metabolism clinics of North America.
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2009
Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus.
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2009
Autologous umbilical cord blood transfusion in very young children with type 1 diabetes.
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2009
Challenges in developing endpoints for type 1 diabetes intervention studies.
Diabetes/metabolism research and reviews.
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2009
Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model.
The ISME journal.
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2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
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2009
Influence of fecal sample storage on bacterial community diversity.
The open microbiology journal.
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2009
Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.
PloS one.
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2009
Network for Pancreatic Organ Donors With Diabetes (Npod): Donor Demographics and Early Progress Report
Hormone Research.
72:156-157
2009
Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area.
Diabetologia.
52(2):262-70
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2009
Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1.
Diabetes care.
32(12):2269-74
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2009
Participant and parent experiences in the oral insulin study of the Diabetes Prevention Trial for Type 1 Diabetes.
Pediatric diabetes.
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2009
Rituximab, B-lymphocyte depletion, and preservation of beta-cell function.
The New England journal of medicine.
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2009
Seroconversion in the Dpt-1 Study: Evidence of Triggering of Autoimmune Process At Different Ages
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The road not taken: a path to curing type 1 diabetes?
European journal of immunology.
39(8):2054-8
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2009
Vitamin D levels in subjects with and without type 1 diabetes residing in a solar rich environment.
Diabetes care.
32(11):1977-9
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2008
Autologous umbilical cord blood infusion for type 1 diabetes.
Experimental hematology.
36(6):710-5
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2008
CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes.
Cytokine.
44(1):154-9
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2008
Cytokines and type 1 diabetes complications: casual or causal association?
Pediatric diabetes.
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2008
Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency.
Annals of the New York Academy of Sciences.
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2008
Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice.
Clinical and experimental immunology.
154(1):15-21
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2008
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
Diabetes.
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2008
Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes.
Pediatric research.
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2008
The IDS conducts standardization of assays for the measurement of autoantibodies and of T cells in autoimmune diabetes. Preface.
Annals of the New York Academy of Sciences.
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2008
The rosigliazone meta-analysis: lessons for the future.
Diabetes care.
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2008
Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy.
The Journal of clinical endocrinology and metabolism.
93(1):26-31
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2008
What’s in a name? Thyroid autoimmunity in obese patients with T1D.
Pediatric diabetes.
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Adverse impact of temperature and humidity on blood glucose monitoring reliability: a pilot study.
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2007
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2007
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No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes.
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Participant and parent experiences in the parenteral insulin arm of the diabetes prevention trial for type 1 diabetes.
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Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes.
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2007
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2007
Type 1 diabetes intervention trials 2007: where are we and where are we going?
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2006
Assessing the utility of SELDI-TOF and model averaging for serum proteomic biomarker discovery.
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2006
Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.
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2006
Maternal understanding of infant diabetes risk: differential effects of maternal anxiety and depression.
Genetics in medicine : official journal of the American College of Medical Genetics.
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2006
Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetes.
The Journal of clinical endocrinology and metabolism.
91(5):1705-13
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2006
The application of genomic and proteomic technologies in predictive, preventive and personalized medicine.
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2005
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Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes.
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Ecological implications of the emergence of non-toxic subcultures from toxic Microcystis strains.
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2005
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes.
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2005
High frequency of abnormal glucose tolerance in DQA1*0102/DQB1*0602 relatives identified as part of the Diabetes Prevention Trial–Type 1 Diabetes.
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Islet cell autoantibodies: a case of a premature obituary.
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2005
Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes.
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2004
Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes.
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Blood lymphocyte chimerism associated with IVF and monochorionic dizygous twinning: case report.
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2004
Diabetes care at diabetes camps.
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Diabetes care in the school and day care setting.
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Maternal anxiety associated with newborn genetic screening for type 1 diabetes.
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2003
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Prospective assessment in newborns of diabetes autoimmunity (PANDA): maternal understanding of infant diabetes risk.
Genetics in medicine : official journal of the American College of Medical Genetics.
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2003
Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes.
The Journal of clinical endocrinology and metabolism.
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Vaccine therapies for the prevention of type 1 diabetes mellitus.
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Type 1 diabetes islet autoantibody markers.
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2002
Use of in vitro-generated, stem cell-derived islets to cure type 1 diabetes: how close are we?
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First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetes.
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Pancreatic stem cells: a therapeutic agent that may offer the best approach for curing type 1 diabetes.
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2001
Prediction and prevention of type 1 diabetes.
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Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT).
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Glutamic acid decarboxylase and IA-2 autoantibodies in type 1 diabetes: comparing sample substrates for autoantibody determinations.
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2000
Islet cell antibody-positive relatives with human leukocyte antigen DQA1*0102, DQB1*0602: identification by the Diabetes Prevention Trial-type 1.
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Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells.
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The relationship of maternal personality characteristics to birth outcomes and infant development.
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Therapeutic controversy: prevention and treatment of diabetes in children.
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Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus.
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1996
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1996
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1996
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Grants
Oct 2023
ACTIVE
Network for Pancreatic Organ Donors – nPOD
Role: Co-Investigator
Funding: JDRF
Jul 2023
ACTIVE
Together: Transforming and Translating Discovery to Improve Health
Role: Faculty
Funding: NATL INST OF HLTH NCATS
Jun 2023
ACTIVE
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2023
– Dec 2023
Data Coordinating Center for the Consortium for Identification of Environmental Determinants of Diabetes in the Young (TEDDY) Study
Role: Principal Investigator
Funding: AUGUSTA UNIVERSITY
via NATL INST OF HLTH NIDDK
Sep 2022
ACTIVE
Survival and potential of insulin-deficient beta cells in type 1 diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Aug 2022
ACTIVE
Biorepository and Coordinating Center for Studies on Cardiovascular Complications of Human Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2022
ACTIVE
Regional Perinatal Intensive Care Center (RPICC) COQYJ Renewal FY22-25
Role: Project Manager
Funding: FL DEPT OF HLTH CHILDRENS MED SERVS
Jul 2022
ACTIVE
Together: Transforming and Translating Discovery to Improve Health
Role: Faculty
Funding: NATL INST OF HLTH NCATS
Feb 2022
– Jan 2024
A T cell phenotype signature driven dose finding study with siplizumab in type 1 diabetes mellitus
Role: Principal Investigator
Funding: BENAROYA RES INST AT VA MASON
via NATL INST OF HLTH NIAID
Sep 2021
ACTIVE
Natural History and Mechanisms of Exocrine Pancreatic Dysfunction in Pre-Type 1 Diabetes
Role: Other
Funding: NATL INST OF HLTH NIDDK
May 2021
– Sep 2023
The Network for Pancreatic Organ donors with Diabetes (nPOD) : A Collaborative Type 1 Diabetes Research Project
Role: Project Manager
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Oct 2020
– Mar 2023
Data Coordinating Center for the Consortium for Identification of Environmental Determinants of Diabetes in the Young (TEDDY) Study.
Role: Principal Investigator
Funding: AUGUSTA UNIVERSITY
via NATL INST OF HLTH NIDDK
Aug 2020
ACTIVE
Understanding pancreatic endocrine and exocrine loss in pre-type 1 diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Feb 2020
ACTIVE
TrialNet Clinical Center infrastructure support services
Role: Co-Investigator
Funding: UNIV OF SOUTH FLORIDA
via NATL INST OF HLTH NIDDK
Feb 2020
– Jan 2023
Human Atlas of Neonatal Developmental and Early Life Pancreas / Immunity (HANDEL)-P/I Continuation
Role: Co-Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Jan 2020
– Jan 2022
A Global, Phase 1/2, Open Label, Dose Escalation Study to Evaluate the Safety, Pharmacodynamics, and Pharmacokinetics of mRNA-3704 in Patients with Isolated Methylmalonic Acidemia Due to Methylmalonyl-CoA Mutase Deficiency
Role: Principal Investigator
Funding: IQVIA Holdings
via MODERNA THERAPEUTICS
Jan 2020
– Apr 2021
Mechanisms of Exocrine Dysfunction in Type 1 Diabetes
Role: Other
Funding: PEDIATRIC ENDOCRINE SOCIETY
Jan 2020
– Dec 2021
Mechanisms of Exocrine Dysfunction in Type 1 Diabetes
Role: Other
Funding: ENDOCRINE FELLOWS FOU
Dec 2019
ACTIVE
MED202 – Regional Perinatal Intensive Care Centers Program (RPICC) Data System FY19-25
Role: Project Manager
Funding: AGCY FOR HLTH CARE ADMN
via US DEPT OF HLTH AND HUMAN SER
Jul 2019
– Jun 2023
Early Steps Data Systems Operation (ESDS) – COQXV
Role: Principal Investigator
Funding: FL DEPT OF HLTH CHILDRENS MED SERVS
via US DEPT OF EDUCATION
Jul 2019
– Jun 2020
TrialNet Affiliate Services
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA
via NATL INST OF HLTH NIDDK
Jun 2019
– Dec 2021
A Randomized, Double blind, Active Control Study of the Safety and Efficacy of PRX-102 compared to Agalsidase Beta on Renal Function in Patients with Fabry Disease Previously Treated With Agalsidase Beta
Role: Principal Investigator
Funding: PROTALIX BIOTHERAPEUTICS
Apr 2019
– Sep 2020
Data Coordinating Center for the Consortium for Identification of Environmental Determinants of Diabetes in the Young (TEDDY)
Role: Principal Investigator
Funding: AUGUSTA UNIVERSITY
via NATL INST OF HLTH NIDDK
Nov 2018
– Oct 2019
Collaborative Research Group – Diabetes and Obesity
Role: Principal Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via PATIENT-CENTERED OUTCOMES RES INST
Sep 2018
– May 2020
Use of MD Logic Automated Insulin Delivery System: Safety and Efficacy
Role: Principal Investigator
Funding: HEALTHPARTNERS INST FOR EDU AND RES
via NATL INST OF HLTH NIDDK
Sep 2018
– Aug 2021
Identification of Anti-Neo-Antigen AutoAntibodies in Type 1 Diabetes
Role: Co-Investigator
Funding: ARIZONA STATE UNIVERSITY
via NATL INST OF HLTH NIDDK
Sep 2018
– Dec 2023
The TEDDY Study: Georgia/Florida Clinical Center
Role: Principal Investigator
Funding: AUGUSTA UNIVERSITY
via NATL INST OF HLTH NIDDK
Jul 2018
ACTIVE
Regenerative Medicine Training Grant
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2018
– Jun 2019
TrialNet Affiliate Services
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA
via NATL INST OF HLTH NIDDK
Jun 2018
– May 2023
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2018
– Aug 2018
Data Coordinating Center for the Consortium for Identificaiton of Environmental Determinants of Diabetes in the Young (TEDDY) Study (GAP Funding)
Role: Principal Investigator
Funding: AUGUSTA UNIVERSITY
via NATL INST OF HLTH NIDDK
May 2018
– Apr 2023
CTOA
Role: Principal Investigator
Funding: UNIV OF FLORIDA
Apr 2018
– Sep 2023
Network for Pancreatic Organ Donors – nPOD
Role: Co-Investigator
Funding: JDRF
Apr 2018
– Jun 2023
FLDOH CMS Disease Management Contract – COQWY: Pediatric Pulmonary Center Training Program – Family Support
Role: Principal Investigator
Funding: FL DEPT OF HLTH CHILDRENS MED SERVS
via US HLTH RESOURCES AND SERV ADMN
Apr 2018
– Jul 2019
Together: Transforming and Translating Discovery to Improve Health
Role: Other
Funding: NATL INST OF HLTH NCATS
Apr 2018
– Mar 2019
Data Coordinating Center for the Consortium for Identification of Environmental Determinants of Diabetes In the Young (TEDDY) "Study"
Role: Principal Investigator
Funding: AUGUSTA UNIVERSITY
via NATL INST OF HLTH NIDDK
Jan 2018
– Sep 2023
Collaborative Type 1 Diabetes Research Project: The Network for Pancreatic Organ donors with Diabetes (nPOD)
Role: Co-Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Jan 2018
– Jun 2022
Regional Perinatal Intensive Care Center (RPICC)
Role: Principal Investigator
Funding: FL DEPT OF HLTH CHILDRENS MED SERVS
Sep 2017
– May 2022
Non-invasive detection of cell death in type 1 diabetes: insight into novel disease mechanisms.
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Aug 2017
– Jul 2018
Low-Dose IL-2 in Established T1D
Role: Principal Investigator
Funding: UNIV OF MIAMI
via NATL INST OF HLTH NIAID
Jul 2017
– Jul 2022
Evaluation of the DreaMed Advice4U for Automated Insulin Pump Settings Adjustments in Children and Adolescents with Type 1 Diabetes.
Role: Principal Investigator
Funding: SCHNEIDER CHILDRENS MED CTR OF ISRAEL
via HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Jul 2017
– Jun 2018
TrialNet Affiliate Services FY 17-18
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA
via NATL INST OF HLTH NIDDK
Apr 2017
– Mar 2018
Together: Transforming and Translating Discovery to Improve Health
Role: Faculty
Funding: NATL INST OF HLTH NCATS
Jan 2017
– Oct 2018
Diabetes and Obesity Collaborative Research Group
Role: Principal Investigator
Funding: VANDERBILT UNIVERSITY MEDICAL CENTER
via PATIENT-CENTERED OUTCOMES RES INST
Sep 2016
– Sep 2018
Home Use of MD-Logic Automated Insulin Delivery System: Safety and Efficacy.
Role: Principal Investigator
Funding: HEALTHPARTNERS INST FOR EDU AND RES
via NATL INST OF HLTH NIDDK
Jul 2016
– Jun 2023
FLDOH CMS Disease Management Contract – COQWY
Role: Principal Investigator
Funding: FL DEPT OF HLTH CHILDRENS MED SERVS
Jul 2016
– Jun 2017
TrialNet Affiliate Services
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA
via NATL INST OF HLTH
Jun 2016
– May 2018
Reimbursement Payments for Physicians Efforts.
Role: Principal Investigator
Funding: AUGUSTA UNIVERSITY
via NATL INST OF HLTH
May 2016
– Sep 2021
Efficacy and Safety of Faster-acting Insulin Aspart compared to NovoRapid? both in Combination with Insulin Degludec in Children and Adolescents with Type 1 Diabetes
Role: Principal Investigator
Funding: NOVO NORDISK
Jan 2016
– Apr 2022
A MULTI CENTER EXTENSION STUDY OF PRX-102 ADMINISTERED BY INTRAVENOUS INFUSIONS EVERY 2 WEEKS FOR 24 MONTHS TO ADULT
Role: Principal Investigator
Funding: PROTALIX BIOTHERAPEUTICS
Oct 2015
– Jun 2019
Early Steps Data System Operation (ESDS)
Role: Principal Investigator
Funding: FL DEPT OF HLTH CHILDRENS MED SERVS
via US DEPT OF EDUCATION
Jul 2015
– Jun 2016
Trialnet affiliate services
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA
Jun 2015
– May 2016
Reimbursement Payments for Physicians Efforts
Role: Principal Investigator
Funding: *GEORGIA REGENTS UNIVERSITY
via NATL INST OF HLTH
Feb 2015
– Jun 2019
MED 164 – Regional Perinatal Intensive Care Centers Program (RPICC) Date System
Role: Principal Investigator
Funding: AGCY FOR HLTH CARE ADMN
via US DEPT OF HLTH AND HUMAN SER
Jan 2015
– Dec 2019
Pediatric Salary Support Fund – Srivastava Lab
Role: Principal Investigator
Funding: UF FOUNDATION
Sep 2014
– Aug 2018
Non-invasive diagnosis of human beta cell damage and death
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2014
ACTIVE
214 CLINICAL TRIAL OPERATION ACCOUNT
Role: Principal Investigator
Funding: 214 OPERATING ACCOUNT
Sep 2014
– Jan 2020
EXTEND – Preserving Beta-Cell Function with Tocilizumab in new Onset Type 1 Diabetes
Role: Principal Investigator
Funding: BENAROYA RES INST AT VA MASON
via NATL INST OF HLTH NIAID
Jun 2014
– Apr 2020
TrialNet: University of Florida Clinical Center and Network
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Jun 2013
– May 2018
Consortium for Identification of Environmental Triggers
Role: Principal Investigator
Funding: GEORGIA HLTH SCIENCES UNIV
via NATL INST OF HLTH NIDDK
May 2013
– Jun 2018
Immune Function and the Progression to Type 1 Diabetes
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Aug 2012
– Mar 2018
A randomized, double-blind, multiple dose, placebocontrolled study to evaluate the safety, tolerability, immunogenicity, pharmacokinetics, and efficacy of secukinumab in adult and pediatric patients with new-onset type 1 diabetes mellitus (T1D)
Role: Principal Investigator
Funding: NOVARTIS US
Aug 2012
– Dec 2020
New Areas of Research
Role: Principal Investigator
Funding: UF FOUNDATION
Oct 2010
– Mar 2019
T1D Exchange Type 1 Diabetes Network
Role: Principal Investigator
Funding: JAEB CTR FOR HLTH RES
via HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Nov 2005
– Dec 2020
Children's Research Initiative
Role: Principal Investigator
Funding: UF FOUNDATION
Education
Fellowship – Pediatric Endocrinology
1989
·
University of Florida
Residency – Pediatrics
1986
·
University of Florida
Internship – Pediatrics
1984
·
University of Florida
Bachelor of Medicine, Bachelor of Surgery
1979
·
University of Witwatersrand
Contact Details
Phones:
- Business:
- (352) 273-9270
Emails:
- Business:
- schatz@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100296
GAINESVILLE FL 32610 - Business Street:
-
PO Box 100296
GAINESVILLE FL 32610