04/11/2024
Research Article
Confounding in GWAS
GWASs aim to estimate direct effects of genotype on an individual's phenotype, but this can be subject to genetic and environmental confounds and "indirect" genetic effects of relatives' genotypes. Carl Veller and Graham Coop present a theoretical analysis of the influence of confounders in population-based and within-family GWASs, showing that, while family-based studies are more rigorous, they still carry subtle issues that arise from confounding. Also read the accompanying Primer by Alexander Young.
Image credit: pbio.3002568
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